Rhodiola rosea contains a variety of compounds that may contribute to its effects,
including the class of rosavins which include rosavin, rosarin, and rosin.
Several studies have suggested that the most active components are likely to be rhodioloside and tyrosol,with other components being inactive when administered alone,but showing synergistic effects when a fixed combination of rhodioloside, rosavin, rosarin and rosin was used.
Although rosavin, rosarin, rosin and salidroside (and sometimes p-tyrosol, rhodioniside, rhodiolin and rosiridin)are among suspected active ingredients of Rhodiola rosea,these compounds are mostly polyphenols for which no physiological effect in humans is proved to prevent or reduce risk of disease.
Although these phytochemicals are typically mentioned as specific to Rhodiola extracts,there are many other constituent phenolic antioxidants, including proanthocyanidins,quercetin, gallic acid, chlorogenic acid and kaempferol.
While animal tests have suggested a variety of beneficial effects for Rhodiola rosea extracts there is scientific evidence only for depression as a benefit in humans.
A clinical trial showed significant effect for a Rhodiola extract in doses of 340–680 mg per day in male and female patients from 18 to 70 years old with mild to moderate depression.
Rodiola Rosea promotes the release of NO from rat penile corpus cavernosum smooth muscle cell and artery endothelium cell, which was correlated with the effect of Rodiola Rosea to resist senility.
Rhodiola rosea extract exerts an anti-fatigue effect that increases mental performance,
particularly the ability to concentrate in healthy subjects and burnout patients with fatigue syndrome.
Rhodiola significantly reduced symptoms of fatigue and improved attention after four weeks of repeated administration.
Salidroside (Rhodioloside) is a glucoside of tyrosol found in the plant Rhodiola rosea.
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